According to 49 CFR 107.601, anyone that ships the following hazardous materials must register with the Department of Transportation:

• A highway route-controlled quantity of Class 7 (radioactive) materials
• More than 25 kilograms of a Division 1.1, 1.2, 1.3 (explosive) material in a motor vehicle, rail car, or freight container
• A package containing more than 1 liter of a material considered extremely toxic by inhalation
• A hazardous material in a bulk package, container, or tank with a capacity equal to or greater than 13,248 liters of liquid or gases or more than 13.24 cubic meters for solids
• A shipment in a non-bulk package of 2,268 kilograms or more gross weight of one class of hazardous materials for which placarding of a vehicle, rail car, or freight container is required
• A quantity of hazardous material that requires placarding (this requirement does not apply to those activities of a farmer, as defined in 49 CFR 171.8, that are in direct support of farming operations) If you fall into any of the above categories, you must submit a complete and accurate registration statement on DOT Form F 5800.2 no later than June 30 for each registration year and pay the applicable registration and processing fees. The fee schedule is as follows:
  
  • Registrants meeting the U.S. Small Business Administration’s criteria defining a small business: $250 per year and a $25 processing fee
  • All other registrants: $975 per year and a $25 processing fee

  Federal, state, or state political subdivision agencies or their employees are not required to register.